IntroductionMuch drug development and published analysis for epithelial ovarian cancer (EOC) focuses on early-line treatment.Full sequences of treatment from diagnosis to death and the impact of later lines of therapy are rarely studied.We describe the establishment of an international network of cancer centers configured to compare real-world trea
Flubendazole (FLU), an anthelmintic drug of benzimidazole type, is now considered a promising anti-cancer agent due to its tubulin binding ability and low system toxicity.The present study was aimed at determining more information about FLU reduction in human liver, because this information has been insufficient until now.Subcellular fractions from
Dravet Syndrome (DS) is most often caused by heterozygous loss-of-function mutations in the voltage-gated sodium channel gene SCN1A (Nav1.1), resulting in severe epilepsy and neurodevelopmental impairment thought to be cause by reduced interneuron excitability.However, recent studies in mouse models suggest that interneuron dysfunction alone does n
OBJECTIVE: To assess the contraceptive effectiveness of condoms versus oral contraceptive pills and estimate the reproductive consequences of a major shift from pill to condom use.METHODS: Secondary analysis was performed on nationally representative cross-sectional surveys of women in 16 developing countries.FINDINGS: In the 16 countries, the medi
The Bottles diagnostics of financial sustainability of economic subjects and the risk of bankruptcy constantly attract the attention of economists.For these purposes, a number of financial indicators have been studied and threshold values were set, above and below which the probability of bankruptcy is considered significant.The agricultural sector